What is this medicine?
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ESTRADIOL (es tra DYE ole) skin patches contain an estrogen. It is mostly used as hormone replacement in menopausal women. It helps to treat hot flashes and prevent osteoporosis. It is also used to treat women with low estrogen levels or those who have had their ovaries removed.
How should I use this medicine?
Estrogen is the primary “female” hormone. It is involved in many of the physical and emotional changes seen in transition. Estrogen may be given as a pill, by injection, or by a number of skin preparations such as a gel, spray or a patch. Pills are convenient, cheap and effective, but are less safe if you smoke or are older than 35. Preferably free from hair. When changing your patch, stick the new patch on to a different area of the skin of your abdomen, otherwise you are more likely to cause skin irritation. Only one patch is to be worn at a time. If you are also using estrogen patches, make sure that the Intrinsa patch and the estrogen patch do not overlap. Similar skin irritation was observed after application of either a matrix or reservoir patch containing fentanyl to the skin of healthy human subjects 99. Impact of formulation on skin irritation.
This medicine is for external use only. Follow the directions on the prescription label. Tear open the pouch, do not use scissors. Remove the stiff protective liner covering the adhesive. Try not to touch the adhesive. Apply the patch, sticky side to the skin, to an area that is clean, dry and hairless. Avoid injured, irritated, calloused, or scarred areas. Do not apply the skin patches to your breasts or around the waistline. Use a different site each time to prevent skin irritation. Do not cut or trim the patch. Do not stop using except on the advice of your doctor or health care professional. Do not wear more than one patch at a time unless you are told to do so by your doctor or health care professional.
Contact your pediatrician regarding the use of this medicine in children. Special care may be needed.
- (2 days ago) Estradiol Patch offers may be in the form of a printable coupon, rebate, savings card, trial offer, or free samples. Some offers may be printed right from a website, others require registration, completing a questionnaire, or obtaining a sample from the doctor's office.
- Skin irritation (erythema and edema), patch adherence and local skin reaction were assessed following patch removal. In Study 1, baseline-uncorrected C(max) for estradiol for Estradot 50 and 100.
A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
breast tissue changes or discharge
changes in vision
chest pain
confusion, trouble speaking or understanding
dark urine
general ill feeling or flu-like symptoms
light-colored stools
nausea, vomiting
pain, swelling, warmth in the leg
right upper belly pain
severe headaches
shortness of breath
sudden numbness or weakness of the face, arm or leg
trouble walking, dizziness, loss of balance or coordination
unusual vaginal bleeding
yellowing of the eyes or skin
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
hair loss
increased hunger or thirst
increased urination
symptoms of vaginal infection like itching, irritation or unusual discharge
unusually weak or tired
What may interact with this medicine?
Do not take this medicine with any of the following medications:
aromatase inhibitors like aminoglutethimide, anastrozole, exemestane, letrozole, testolactone
This medicine may also interact with the following medications:
carbamazepine
certain antibiotics used to treat infections
certain barbiturates used for inducing sleep or treating seizures
grapefruit juice
medicines for fungus infections like itraconazole and ketoconazole
raloxifene or tamoxifen
rifabutin, rifampin, or rifapentine
ritonavir
St. John's Wort
What if I miss a dose?
If you miss a dose, apply it as soon as you can. If it is almost time for your next dose, apply only that dose. Do not apply double or extra doses.
Where should I keep my medicine?
Keep out of the reach of children.
Store at room temperature below 30 degrees C (86 degrees F). Do not store any patches that have been removed from their protective pouch. Throw away any unused medicine after the expiration date. Dispose of used patches properly. Since used patches may still contain active hormones, fold the patch in half so that it sticks to itself prior to disposal.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
abnormal vaginal bleeding
blood vessel disease or blood clots
breast, cervical, endometrial, ovarian, liver, or uterine cancer
dementia
diabetes
gallbladder disease
heart disease or recent heart attack
high blood pressure
high cholesterol
high level of calcium in the blood
hysterectomy
kidney disease
liver disease
migraine headaches
protein C deficiency
protein S deficiency
stroke
systemic lupus erythematosus (SLE)
tobacco smoker
an unusual or allergic reaction to estrogens, other hormones, medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
breast-feeding
What should I watch for while using this medicine?
Visit your doctor or health care professional for regular checks on your progress. You will need a regular breast and pelvic exam and Pap smear while on this medicine. You should also discuss the need for regular mammograms with your health care professional, and follow his or her guidelines for these tests.
This medicine can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your doctor or health care professional if you feel you are retaining fluid.
If you have any reason to think you are pregnant, stop taking this medicine right away and contact your doctor or health care professional.
Smoking increases the risk of getting a blood clot or having a stroke while you are taking this medicine, especially if you are more than 35 years old. You are strongly advised not to smoke.
If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your eye doctor or health care professional.
This medicine can increase the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, with this medicine lowers the risk of developing this condition. Therefore, if your uterus has not been removed (by a hysterectomy), your doctor may prescribe a progestin for you to take together with your estrogen. You should know, however, that taking estrogens with progestins may have additional health risks. You should discuss the use of estrogens and progestins with your health care professional to determine the benefits and risks for you.
If you are going to have surgery or an MRI, you may need to stop taking this medicine. Consult your health care professional for advice before you schedule the surgery.
Contact with water while you are swimming, using a sauna, bathing, or showering may cause the patch to fall off. If your patch falls off reapply it. If you cannot reapply the patch, apply a new patch to another area and continue to follow your usual dose schedule.
Online Medical Reviewer:
Date Last Reviewed: Unavailable
NOTE:This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Copyright© 2019 Elsevier
Related Conditions
It may begin with redness, but it may not be noticeable until there are little red dots, or the skin may peel up, or there may be frank blisters. Sometimes there is itching; sometimes not. What's going on? And can we ignore these signs and have them go away?
A common response, but not an allergy
We hate to have to say this but yes, many women have this issue and it's usually an indication that the particular patch isn't going to work out for them. That's too bad, because we know what a triumph it is to finally find an hrt that suits your body.
But the truth is that this usually represents a sensitivity reaction to either the ingredients of the adhesive or to the simple fact of having an impermeable (non-breathing) barrier on your skin for that amount of time. It's not necessarily an allergy and it doesn't at all represent an allergy to the estradiol (or the vegetable source from which it's refined). Please be clear on this. We see women passing along a lot of misinformation about this kind of problem every day, and hrts are difficult enough in themselves without borrowing complications based upon myths.
The question is what you can do about it, of course.
First of all, putting some sort of skin treatment under that patch will interfere with the transfer of hormones into your body and/or the patch's adhesion to your skin. So that's out. Don't bother.
Treating the irritated area after the patch is removed with a mild otc steroid cream may sometimes help it resolve sooner, but won't prevent it happening at the next location. And not all women should use those steroid creams, so run this past your doctor unless you know for sure that it's okay for you.
And here's where the whole sorting-for-the-negative thing on the internet comes into it. We don't actually know the proportion of situations in which this inevitably progresses to an extent that prevents continuing with the patch. The reports that women post suggest that the irritation continues and worsens, but it could be that there is a large body of women out there, not bothering to mention this, who simply have mild irritation and nothing more. We don't think this is especially the case, but if you are only having a mild reaction and really want to push it further to see what happens, that's an option. You probably won't hurt yourself, other than a risk of discomfort and perhaps light scarring, if you continue and wait to see how it goes. Again, we don't think this is a strategy that will particularly work, but we can't say that it won't, for sure, either.
No, really, it's probably going to mean changing brands
The remaining options, as you may have guessed by now, have to do with changing brands or hrts.
If the patch is otherwise suiting you, then it certainly makes sense to explore the other brands of estradiol patches. Each one differs in the adhesive ingredients and that is the most likely source of your skin reaction, so changing brands holds the most likely chance of dodging the skin reaction while keeping the good hrt delivery dynamic. But because these adhesive differences also mean differences in how the hormones are transported into your body, you may need to try more than one brand to find a good match.
This is where samples from the doctor's office are helpful. You should be able to get the same dose, and they are equivalent across patches, so that isn't something you'll need to worry about to begin with (although transfer differences from the different adhesives may ultimately require a small dose tweak). As a general rule, we read a lot of reports detesting the generic estradiol patch: it's large and thick and stiff and really doesn't seem to adhere well at all, giving it a poor delivery consistency. Otherwise, there are women who have found good success with each brand, so your odds are actually fairly good of finding a good substitute.
But what if they all make me break out?
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All that above about adhesives assumes that the problem is a reaction to the specific ingredients rather than your skin's displeasure at being covered so long. If you're a woman who has always had problems with blisters under a bandaid or can't wear non-breathing fabrics without a heat rash, you might instead simply be having a mechanical problem to do with ventilation.Download Free Skin Irritation Estrogen Patch Software Patch
If that is the problem, then no patch is likely to be suitable for you—there's no patch that allows the skin underneath to breathe. If that's the case, then it will be necessary to look at alternative hrts. Perhaps some of the other transdermals—a gel or cream or vaginal form—or maybe a transbuccal delivery will work for you in an equally satisfactory way.